1207187-93-6

Basic information

• Product Name: tert-butyl (S)-1-(methoxycarbonyl)-2-(1-(4-isopropoxy-6-phenylpyrimidin-2-yl)-1H-imidazol-4-yl)ethylcarbamate
• Synonyms: tert-butyl (S)-1-(methoxycarbonyl)-2-(1-(4-isopropoxy-6-phenylpyrimidin-2-yl)-1H-imidazol-4-yl)ethylcarbamate
• CAS NO: 1207187-93-6
• Molecular Weight: 481.552
• Mol File: 1207187-93-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (S)-1-(methoxycarbonyl)-2-(1-(4-isopropoxy-6-phenylpyrimidin-2-yl)-1H-imidazol-4-yl)ethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-1-(methoxycarbonyl)-2-(1-(4-isopropoxy-6-phenylpyrimidin-2-yl)-1H-imidazol-4-yl)ethylcarbamate(1207187-93-6)
• EPA Substance Registry System: tert-butyl (S)-1-(methoxycarbonyl)-2-(1-(4-isopropoxy-6-phenylpyrimidin-2-yl)-1H-imidazol-4-yl)ethylcarbamate(1207187-93-6)

Safety Data

• Hazardous Substances Data: 1207187-93-6(Hazardous Substances Data)

Upstream product

• 2488-14-4 N-(tert-butoxycarbonyl)-L-histidine methyl ester 
• 497944-67-9 4-isopropoxy-6-phenyl-2-phenylmethanesulfonyl-pyrimidine 

Relevant articles and documents

A simple approach for the synthesis of new pyrimidinyl α-amino acids

A simple synthetic method for the preparation of optically active pyrimidinyl α-amino acids is presented. A nucleophilic ipso-substitution reaction between 2-(benzylsulfonyl)-4-isopropoxypyrimidines and a nucleophilic side chain of several protected natural α-amino acids is investigated to obtain new pyrimidin-2-yl α-amino acids. A detailed optimisation study of this reaction is discussed. Moreover, the selective O-alkylation of 2-(benzylsulfanyl)-4(3H)pyrimidinones with a hydroxylic side chain of some natural α-amino acids under Mitsunobu conditions is studied as a method to prepare new pyrimidin-4-yl α-aminoesters.