1207192-25-3Relevant academic research and scientific papers
DBU-promoted alkylation of alkyl phosphinates and H-phosphonates
Gavara, Laurent,Petit, Christelle,Montchamp, Jean-Luc
supporting information, p. 5000 - 5003 (2012/11/07)
The alkylation of alkyl phosphinates and some H-phosphonate diesters is promoted by the base DBU. Only more reactive alkyl halides react in preparatively useful yields. However, the method provides easy access to important H-phosphinate building blocks, without the need for a protecting group strategy or metal catalysts. The reaction is conveniently conducted at, or below, room temperature. The preparation of methyl-H-phosphinate esters is particularly interesting as it avoids the heretofore more common use of methyldichlorophosphine MePCl2.
Chemistry of the versatile (hydroxymethyl)phosphinyl P(O)CH2OH functional group
Berger, Olivier,Gavara, Laurent,Montchamp, Jean-Luc
supporting information; experimental part, p. 3404 - 3407 (2012/09/08)
(Hydroxymethyl)phosphorus compounds are well-known and valuable compounds in general; however the use of (hydroxymethyl)phosphinates R1P(O) (OR2)CH2OH in particular has been much more limited. The potential of this functio
Facile P,N-heterocycle synthesis via tandem aminomethylation-cyclization of H-phosphinate building blocks
Queffelec, Clemence,Montchamp, Jean-Luc
supporting information; experimental part, p. 267 - 273 (2010/04/24)
Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks. Aminomethylation of these H-phosphinates is followed by in situ cyclization through substitution or cross-coupling to prod
Temporary protection of H-phosphinic acids as a synthetic strategy
Coudray, Laetitia,Montchamp, Jean-Luc
supporting information; experimental part, p. 4646 - 4654 (2009/12/06)
H-Phosphinates obtained through, various methodologies are protected directly by the reaction with triethyl orthoacetate. The resulting products can be manipulated easily, and various synthetic reactions are presented. For example, application to the synt
