1207192-41-3

Upstream product

• 1207192-23-1 ethyl (2-bromobenzyl)-H-phosphinate 
• 4393-14-0 N-methylenebenzylamine 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 2547-66-2 1,3,5-Tribenzyl-1,3,5-triazacyclohexane 

Relevant academic research and scientific papers

DBU-promoted alkylation of alkyl phosphinates and H-phosphonates

The alkylation of alkyl phosphinates and some H-phosphonate diesters is promoted by the base DBU. Only more reactive alkyl halides react in preparatively useful yields. However, the method provides easy access to important H-phosphinate building blocks, without the need for a protecting group strategy or metal catalysts. The reaction is conveniently conducted at, or below, room temperature. The preparation of methyl-H-phosphinate esters is particularly interesting as it avoids the heretofore more common use of methyldichlorophosphine MePCl2.

Facile P,N-heterocycle synthesis via tandem aminomethylation-cyclization of H-phosphinate building blocks

Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks. Aminomethylation of these H-phosphinates is followed by in situ cyclization through substitution or cross-coupling to prod