1207200-44-9Relevant academic research and scientific papers
Highly enantio- And diastereoselective mannich reactions of glycine schiff bases with in situ generated N-boc-imines catalyzed by a cinchona alkaloid thiourea
Zhang, Halle,Syed, Salahuddin,Barbas, Carlos F.
supporting information; experimental part, p. 708 - 711 (2010/04/02)
(Figure Presented) Highly ena(Figure Presented)ntlo- and dlastereoselectlve organocatalytlc Mannlch reactions of glycine Schiff bases with N-Boc-protected lmlnes are described. Imlnes were generated In situ from bench-stable a-amldo sulfones. Catalysis mediated by a cinchona alkaloid thiourea provided optically active α,βdlamlno acid derivatives with up to 99% ee and near-perfect dlastereoselection.
