1207355-21-2Relevant academic research and scientific papers
Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused Indole and Spirooxindole Derivatives
Cai, Ju,Wu, Bing,Rong, Guangwei,Zhang, Cheng,Qiu, Lihua,Xu, Xinfang
, p. 2733 - 2736 (2018)
An unprecedented gold-catalyzed bicyclization reaction of diaryl alkynes has been developed for the synthesis of indoles in good to high yields. Mechanistically, this alkyne bifunctionalization transformation was terminated by a stepwise formal X-H insert
Cu(OTf)2-Catalyzed Intramolecular Radical Cascade Reactions for the Diversity-Oriented Synthesis of Quinoline-Annulated Polyheterocyclic Frameworks
Yuan, Shuo,Zhang, Jingya,Zhang, Danqing,Wei, Donghui,Zuo, Jiahui,Song, Jian,Yu, Bin,Liu, Hong-Min
supporting information, p. 1445 - 1450 (2021/03/03)
Compound libraries with high levels of structural diversity and novelty could cover underexploited chemical space and thus have been highly pursued in drug discovery. Herein, we report the first Cu(OTf)2-catalyzed intramolecular radical cascade reactions
Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition
Debets, Marjoke F.,Van Berkel, Sander S.,Schoffelen, Sanne,Rutjes, Floris P. J. T.,Van Hest, Jan C. M.,Van Delft, Floris L.
supporting information; experimental part, p. 97 - 99 (2010/04/01)
A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.
