1207355-24-5Relevant articles and documents
Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition
Debets, Marjoke F.,Van Berkel, Sander S.,Schoffelen, Sanne,Rutjes, Floris P. J. T.,Van Hest, Jan C. M.,Van Delft, Floris L.
supporting information; experimental part, p. 97 - 99 (2010/04/01)
A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.