1207370-28-2 Usage
General Description
2-pyridinone-6-boronic ester is a chemical compound that is used in organic synthesis and medicinal chemistry. It is a boronic ester derivative of 2-pyridinone, which is a heterocyclic compound commonly found in pharmaceuticals and agrochemicals. The boronic ester functional group is important in organic chemistry as it can undergo various reactions such as Suzuki-Miyaura cross-coupling to form carbon-carbon bonds. This particular compound has potential applications in the synthesis of pharmaceuticals and bioactive molecules due to its unique structure and reactivity. It is also a useful building block for creating new chemical entities with the potential for biological activity. Overall, 2-pyridinone-6-boronic ester is a versatile chemical that plays an important role in the development of new compounds for various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1207370-28-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,7,3,7 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1207370-28:
(9*1)+(8*2)+(7*0)+(6*7)+(5*3)+(4*7)+(3*0)+(2*2)+(1*8)=122
122 % 10 = 2
So 1207370-28-2 is a valid CAS Registry Number.
1207370-28-2Relevant articles and documents
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents
Niculescu-Duvaz, Dan,Niculescu-Duvaz, Ion,Suijkerbuijk, Bart M.J.M.,Ménard, Delphine,Zambon, Alfonso,Davies, Lawrence,Pons, Jean-Francois,Whittaker, Steven,Marais, Richard,Springer, Caroline J.
, p. 1284 - 1304 (2013/03/14)
The RAS-RAF-MEK-ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine-threonine kinase, belonging to this pathway that is mutated with high frequency in human melanoma and other cancers thus BRAF is an important therapeutic target in melanoma. We have designed inhibitors of BRAF based on 2,4,5-trisubstituted imidazoles with naphthyl and benzothiophene-4-substituents. Two compounds were discovered to be potent BRAF inhibitors: 1-(6-{2-[4-(2-dimethylamino-ethoxy)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl} benzo[b]thiophen-3-yl)-2,2,2-trifluoroethanol (1i) with BRAF IC50 = 190 nM and with cellular GI50 = 2100 nM, and 6-{2-[4-(2- dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol (1q) with IC50 = 9 nM and GI50 = 220 nM.
