1207386-23-9

Upstream product

• 123-72-8 butyraldehyde 
• 271600-36-3 N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide 
• 150884-50-7 benzaldehyde N-boc imine 

Relevant academic research and scientific papers

Asymmetric synthesis method of chiral beta-amino aldehyde compound

The invention discloses an asymmetric synthesis method of a chiral beta-amino aldehyde compound as shown in a formula (I) which is described in the specification. The asymmetric synthesis is carried out in an organic solvent with imine as shown in a formula (II) and aldehyde as shown in a formula (III) as reactants. The method is characterized in that the reaction is carried out under the action of a supramolecular catalyst constructed by a chiral catalyst and a polymer, wherein the chiral catalyst is one as described in the specification, and the polymer is PEG and/or PPG. According to the invention, PPG/PEG and the chiral catalyst are utilized to construct the supramolecular catalyst for asymmetric synthesis of the chiral beta-amino aldehyde compound, so product yield is significantly improved.

Asymmetric Aza-Morita-Baylis-Hillman-type reactions: The highly enantioselective reaction between unmodified α,β- unsaturated aldehydes and N-acylimines by organo-co-catalysis

The highly enantioselective organo-co-catalytic aza-Morita-Baylis-Hillman (MBH)-type reaction between N-carbamate-protected imines and α,β-unsaturated aldehydes has been developed. The organic co-catalytic system of proline and 1,4-diazabicyclo[2.2.2]octa

One-pot highly enantioselective catalytic Mannich-type reactions between aldehydes and stable α-amido sulfones: asymmetric synthesis of β-amino aldehydes and β-amino acids

A highly enantioselective catalytic route to carbamate- and benzoate-protected β-amino aldehydes and β-amino acids is presented. The amino acid-catalyzed one-pot asymmetric reaction between unmodified aldehydes and α-amido sulfones gives the corresponding