1207427-09-5

Basic information

• Product Name: ethyl 4-(5-chloro-1-methylimidazol-2-yl)benzoate
• Synonyms: ethyl 4-(5-chloro-1-methylimidazol-2-yl)benzoate
• CAS NO: 1207427-09-5
• Molecular Weight: 264.711
• Mol File: 1207427-09-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-(5-chloro-1-methylimidazol-2-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(5-chloro-1-methylimidazol-2-yl)benzoate(1207427-09-5)
• EPA Substance Registry System: ethyl 4-(5-chloro-1-methylimidazol-2-yl)benzoate(1207427-09-5)

Safety Data

• Hazardous Substances Data: 1207427-09-5(Hazardous Substances Data)

Upstream product

• 872-49-1 N-methyl-5-chloroimidazole 
• 5798-75-4 Ethyl 4-bromobenzoate 

Relevant articles and documents

Modulating reactivity and diverting selectivity in palladium-catalyzed heteroaromatic direct arylation through the use of a chloride activating/blocking group

(Chemical Equation Presented) Through the introduction of an aryl chloride substituent, the selectivity of palladium-catalyzed direct arylation may be diverted to provide alternative regioisomeric products in high yields. In cases where low reactivity is typically observed, the presence of the carbon-chlorine bond can serve to enhance reactivity and provide superior outcomes. From a strategic perspective, the C-Cl bond is easily introduced and can be employed in a variety of subsequent transformations to provide a wealth of highly functionalized heterocycles with minimal substrate preactivation. The impact of the C-Cl functional group on direct arylation reactivity has also been evaluated mechanistically, and the observed reactivity profiles correlate very well with that predicted by a concerted metalation-deprotonation pathway.