1207428-79-2Relevant articles and documents
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Torrisi, Caterina,Bisbocci, Monica,Ingenito, Raffaele,Ontoria, Jesus M.,Rowley, Michael,Schultz-Fademrecht, Carsten,Toniatti, Carlo,Jones, Philip
, p. 448 - 452 (2010)
A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying good cellular activity and promising rat PK properties.