1207451-99-7

Upstream product

• 1207452-07-0 O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1207452-00-3 N₂-dimethylaminomethylene-O₆-(2,4,6-triisopropylbenzenesulfonyl)-2'-O-methyl-3',5'-O-di-tert-butylsilanediylguanosine 

Relevant academic research and scientific papers

Facile and efficient approach for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosine

A convenient method for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosine (1), which is a useful intermediate for oligonucleotide construction, was developed. We chose the di-tert-butylsilyl group and the triisopropylbenzenesulfonyl group as sugar and base protecting groups, respectively. These protecting groups were stable during the 2′-O-methylation step with MeI and NaH. Our six-step synthesis of 1 is easy to perform using commercially available reagents, and requires only three chromatographic purifications. Compound 1 was obtained in 56% yield from guanosine.