1207461-56-0Relevant academic research and scientific papers
Novel synthesis of amphiphilic dendrons by the double-stage convergent method
Shi, Zi-Fa,Chai, Wen-Yu,An, Peng,Cao, Xiao-Ping
supporting information; experimental part, p. 4394 - 4397 (2009/12/26)
A serles of amphophilic dendrons (G1-G4) have been designed and synthesized, which have a highly branched aliphatic hydrocarbon skeleton and a hydrophilic hydroxyl functionality to enable conjugation with other substrates. The higher generation dendrons (G3 and G4) were synthesized by a double-stage convergent method, which shortened the synthetic route significantly and provided the products In an efficient manner. The key branching step involved a double alkyl-metal addition to an ester functionality followed by deoxygenation of a resulting tertiary alcohol by triethylsilane.
