1207462-86-9Relevant articles and documents
Synthesis and anticancer activities of ageladine A and structural analogs
Ma, Yuelong,Nam, Sangkil,Jove, Richard,Yakushijin, Kenichi,Horne, David A.
scheme or table, p. 83 - 86 (2010/04/05)
A series of ageladine A analogs that include 2-aminoimidazo[4,5-c]azepines (seven-membered rings) and 2-amino-3H-imidazo[4,5-c]pyridine (six-membered rings) derivatives were synthesized and evaluated for their anticancer effects against several human cancer cell lines and MMP-2 inhibition in vitro. Only compounds possessing the aromatic azepine (seven-membered ring) core showed anticancer activity with IC50 values in the low micromolar range.