1207476-93-4Relevant articles and documents
Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR
Takayama, Tetsuo,Umemiya, Hiroki,Amada, Hideaki,Yabuuchi, Tetsuya,Shiozawa, Fumiyasu,Katakai, Hironori,Takaoka, Akiko,Yamaguchi, Akie,Endo, Mayumi,Sato, Masakazu
scheme or table, p. 108 - 111 (2010/03/30)
We have described the synthesis, enzyme inhibitory activity, structure-activity relationships, and proposed binding mode of a novel series of pyrrole derivatives as lymphocyte-specific kinase (Lck) inhibitors. The most potent analogs exhibited good enzyme inhibitory activity (IC50s 10 nM) for Lck kinase inhibition.
