120749-39-5

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 133030-42-9 4--1-methylpiperidin-4-ol 
• 104354-53-2 1-methyl-4-phenylthiopiperidine-4-carbaldehyde 
• 121133-01-5 (2RS,3SR)-2,6-dimethylphenyl 3-hydroxy-2-methyl-3-<4'-(1'-methyl-4'-(phenylthio)piperidyl)>propionate 

Downstream Products

• 121133-06-0 (2RS,3SR)-2-methyl-3-(1-methylpiperid-1,2,3,6-tetrahydropyridin-4-yl)-3-phenylthiopropyl benzoate 
• 121133-04-8 (1RS,2RS)-3-(t-butyldiphenylsiloxy)-2-methyl-1-(1-methyl-4-phenylthiopiperidin-4-yl)propan-1-ol 
• 121133-05-9 (2RS,3RS)-3-hydroxy-2-methyl-3-<1'-methyl-4'-(phenylthio)-piperidin-4'-yl>propyl benzoate 
• 120749-40-8 (3RS,4SR)-3,8-dimethyl-4-phenylthio-1-aza-1-oxaspiro<4.5>decane 

Relevant academic research and scientific papers

Stereospecific Phenylthio Migrations in the Synthesis of Spirocyclic Lactones and Ethers from N-Methyl-4-Piperidone and Quinuclidin-3-one

Single diastereoisomers of spirocyclic lactones and ethers have been prepared using intramolecular attack by the oxygen atom of a hydroxy or ester group onto an episulfonium ion.The sulfur group migrates with complete stereospecificity to give the saturat

Transformation of Cyclic α-Phenylthio Aldehydes by Stereoselective Aldol Reactions and Phenylthio Migration into Spirocyclic Lactones and Ethers, and E-Allylic Alcohols with 1,4-Related Chiral Centres

syn- and anti-Selective aldol reactions between enolates of propionate esters and three α-phenylthio cycloalkanecarbaldehydes give single diastereoisomers of phenylthio alcohols which rearrange in acid with 5-hydroxy or 5-CO2H participation to give spiroc

STEREOCHEMICALLY CONTROLLED SYNTHESIS OF SPIROCYCLIC LACTONES AND ETHERS FROM N-METHYL-4-PIPERIDONE AND 3-QUINUCLIDINONE BY PHENYLTHIO MIGRATION

Phenylthio migration coupled to stereoselective aldol reactions provides single diastereoisomers of allylic sulphides and spirocyclic tetrahydrofurans and butenolides based on the piperidine and quinuclidine skeletons.