1207530-75-3Relevant academic research and scientific papers
Acyclic ene-carbamate. A useful tool for an original synthesis of phosphine-containing α-amino acids bearing a quaternary carbon
Bouet, Alexis,Cieslikiewicz, Monika,Lewinski, Krzysztof,Coudert, Gérard,Gillaizeau, Isabelle
experimental part, p. 498 - 503 (2010/03/03)
A novel and efficient approach for the synthesis of phosphine-containing α-amino acids bearing quaternary carbon is described. The key step involves the original nucleophilic addition of lithiated phosphines onto acyclic ene-carbamates concomitant with a spontaneous internal (N→C) alkyloxycarbonyl migration.
