1207548-64-8

Basic information

• Product Name: 4,6-bis(4-chlorophenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione
• Synonyms: 4,6-bis(4-chlorophenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione
• CAS NO: 1207548-64-8
• Molecular Weight: 411.354
• Mol File: 1207548-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,6-bis(4-chlorophenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-bis(4-chlorophenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione(1207548-64-8)
• EPA Substance Registry System: 4,6-bis(4-chlorophenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione(1207548-64-8)

Safety Data

• Hazardous Substances Data: 1207548-64-8(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 17356-08-0 thiourea 
• 1889-71-0 4'-chloro-2-phenylacetophenone 

Relevant articles and documents

Bronsted base-catalyzed one-pot three-component Biginelli-type reaction: An efficient synthesis of 4,5,6-triaryl-3,4-dihydropyrimidin-2(1H)-one and mechanistic study

(Chemical Equation Presented) An efficient one-pot synthesis of 4,5,6-triaryl-3,4-dihydropyrimidin-2(1H)-ones via a three-component Biginelli-type condensation of aldehyde, 2-phenylacetophenone, and urea/thiourea in the presence of a catalytic amount of t-BuOK (20 mol %) is described. The reactions proceeded efficiently at 70 °C to afford the desired products in moderate to good yields. Detailed mechanistic study shows that the Biginelli-type reaction using urea and thiourea proceeds through two totally different pathways. Enone 5 and bis-urea 8 were highly suggested as respective reaction intermediates for reactions involving thiourea and urea as substrates.