1207549-92-5Relevant articles and documents
Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia
Cutshall, Neil S.,Onrust, Rene,Rohde, Alex,Gragerov, Sasha,Hamilton, Lauren,Harbol, Kevin,Shen, Hui-Rong,McKee, Shawn,Zuta, Charles,Gragerova, Galina,Florio, Vince,Wheeler, Thomas N.,Gage, Jennifer L.
, p. 5595 - 5599 (2012/09/21)
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model.