120757-41-7Relevant academic research and scientific papers
Identification and expression analysis of cd73 inhibitors in cervical cancer
Abid, Syed Mobasher Ali,Bano, Sehrish,Basharat, Ayesha,Iqbal, Jamshed,Pelletier, Julie,Sévigny, Jean
, p. 866 - 874 (2021/10/21)
Aims: The present study was conducted to examine the inhibitory effects of synthesized sulfonylhydrazones on the expression of CD73 (ecto-5′-NT). Background: CD73 (ecto-5′-NT) represents the most significant class of ecto-nucleotidases, which are mainly r
3-Formylchromones: Potential antiinflammatory agents
Khan, Khalid M.,Ambreen, Nida,Mughal, Uzma Rasool,Jalil, Saima,Perveen, Shahnaz,Choudhary, M. Iqbal
scheme or table, p. 4058 - 4064 (2010/10/02)
The synthesis and characterization of 3-formylchromone (1) and its derivatives 2-24 and evaluation of their potential antiinflammatory activities is reported here. These compounds were characterized by 1H NMR, EI MS, IR, and UV spectroscopic techniques and elemental analysis. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity and their effects were compared with known standard drug such as aspirin and indomethacin. Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities. The results and SAR has been discussed in this report. The synthesis and potential antiinflammatory activities of 3-formylchromone (1) and its derivatives 2-24 is reported here. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity.
4-Diazomethylcoumarins and Related Stable Heteroaryldiazomethanes. Thermal Conversion into Condensed Pyrazoles
Ito, Keiichi,Maruyama, Junko
, p. 1681 - 1687 (2007/10/02)
4-Diazomethyl-substituted coumarins, 1-methyl-2(1H)-quinolinones, 1-thiocoumarin and their tricyclic analogs were found to be easily cyclized into the corresponding pyrazole isomers condensed with heteroaromatics.Thermodependent feature of these conversio
