1207610-57-8Relevant articles and documents
2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study
Basnet, Arjun,Thapa, Pritam,Karki, Radha,Choi, Hoyoung,Choi, Jae Hun,Yun, Minho,Jeong, Byeong-Seon,Jahng, Yurngdong,Na, Younghwa,Cho, Won-Jea,Kwon, Youngjoo,Lee, Chong-Soon,Lee, Eung-Seok
, p. 42 - 47 (2010)
For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed.