1207615-62-0

Basic information

• Product Name: (Z)-5-((1-(4-nitrobenzyl)-1H-indol-3-yl)methylene)-imidazolidine-2,4-dione
• Synonyms: (Z)-5-((1-(4-nitrobenzyl)-1H-indol-3-yl)methylene)-imidazolidine-2,4-dione
• CAS NO: 1207615-62-0
• Molecular Weight: 362.345
• Mol File: 1207615-62-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-5-((1-(4-nitrobenzyl)-1H-indol-3-yl)methylene)-imidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-((1-(4-nitrobenzyl)-1H-indol-3-yl)methylene)-imidazolidine-2,4-dione(1207615-62-0)
• EPA Substance Registry System: (Z)-5-((1-(4-nitrobenzyl)-1H-indol-3-yl)methylene)-imidazolidine-2,4-dione(1207615-62-0)

Safety Data

• Hazardous Substances Data: 1207615-62-0(Hazardous Substances Data)

Upstream product

• 461-72-3 2,4-imidazolidinedione 
• 192997-25-4 1-[(4-nitrophenyl)methyl]-1H-indole-3-carboxaldehyde 

Relevant articles and documents

INDOLE COMPOUNDS AND THEIR USE AS RADIATION SENSITIZING AGENTS AND CHEMOTHERAPEUTIC AGENTS

Indole derivatives that are useful in the treatment of cancer as a chemotherapeutic agent or radiosensitizing agent.

Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents

A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (9a-9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (10a-10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three analogs, 10a, 10b, and 10c were identified as the most potent radiosensitizing agents.