1207620-29-8Relevant academic research and scientific papers
Expedient synthesis of homochiral 1-aryl-substituted 4,5-dihydro-1H-imidazoles and their modification to N-heterocyclic carbene precursors
Latham, Christopher M.,Lewis, William,Blake, Alexander J.,Woodward, Simon
, p. 1819 - 1823 (2015/05/27)
The amidoamines (S)-Ar1CONHCHRCH2NHAr2 [Ar1 = o-C6H4SO3H, R = Bn, iBu, iPr; Ar2 = 2,6-iPr2C6H4, 2,6-Et2C6H4
Design of chiral hydroxyalkyl- and hydroxyarylazolinium salts as new chelating diaminocarbene ligand precursors devoted to asymmetric copper-catalyzed conjugate addition
Rix, Diane,Labat, Stephane,Toupet, Loic,Crevisy, Christophe,Mauduit, Marc
scheme or table, p. 1989 - 1999 (2009/10/30)
The design and the synthesis of a set of new chiral hy- droxyalkyl- and hydroxyaryl-chelating diaminocarbene ligands is reported. Comparative catalytic studies show the importance of the scaffold design around the NHC unit to obtain a high enantiocontrol in Cu-catalyzed asymmetric conjugate addition (ACA). Whereas low selectivities are observed when the stereogenic centre is placed within the N-heterocyclic ring, an interesting match effect can be observed when central chirality is located within both of the two side chains, which enables up to 92 % ee in the catalysis reaction. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009.
