1207623-74-2Relevant academic research and scientific papers
Chemical delivery system of metaiodobenzylguanidine (MIBG) to the central nervous system
Gourand, Fabienne,Mercey, Guillaume,Ibazizène, Méziane,Tirel, Olivier,Henry, Jo?l,Levacher, Vincent,Perrio, Cécile,Barré, Louisa
experimental part, p. 1281 - 1287 (2010/07/18)
The aim of the present investigation was to apply a chemical delivery system (CDS) to MIBG(4) with the purpose of delivering this drug to the CNS. Compound 4 has been linked to a 1,4-dihydroquinoline moiety in order to achieve its CNS penetration, and here we report the synthesis to link 4 to the chemical delivery system and the radiosynthesis with carbon-11 of the CDS-4 entity . After iv injection into rats of the [11C]CDS-4, the follow-up study of the radioactivity distribution in blood samples and brain homogenates and the analysis by HPLC and LC-MS/MS have confirmed the release of 4 into the CNS.
