1207719-13-8

Basic information

• Product Name: C₄₉H₅₈N₈O₈
• CAS NO: 1207719-13-8
• Molecular Weight: 887.048
• Mol File: 1207719-13-8.mol

Chemical Properties

• CAS DataBase Reference: C₄₉H₅₈N₈O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₉H₅₈N₈O₈(1207719-13-8)
• EPA Substance Registry System: C₄₉H₅₈N₈O₈(1207719-13-8)

Safety Data

• Hazardous Substances Data: 1207719-13-8(Hazardous Substances Data)

Upstream product

• 1160862-49-6 (4R)-methyl 2-[3-(9-fluorenylmethoxycarbonyl)-2,2-dioxo-1,2,3-oxathiazolidin-4-yl]acetate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant articles and documents

Structure-activity analysis of the growth hormone secretagogue GHRP-6 by α- And β-Amino γ-lactam positional scanning

Incorporation of amino lactams into biologically active peptides restricts conformational mobility and may enhance selectivity and increase potency. α- and β-amino γ-lactams (Agl and Bgl), in both S and R configurations, were introduced into the growth hormone secretagogue GHRP-6 using a Fmoc-compatible solid-phase protocol relying on N-alkylation with five- and six-membered cyclic sulfamidates, followed by lactam annulation under microwave heating. Using this protocol in conjunction with IRORI Kan TM techniques furnished eleven new GHRP-6 analogs, and their binding affinity IC50 values on both the growth hormone secretagogue receptor 1a (GHS-R1a) and CD36 receptors are herein reported. The results indicate that selectivity towards one receptor or the other can be modulated by lactam substitution, typically at the Ala3 and the d-Phe5 positions.