1207725-92-5Relevant articles and documents
Structure-guided design of α-amino acid-derived Pin1 inhibitors
Potter, Andrew J.,Ray, Stuart,Gueritz, Louisa,Nunns, Claire L.,Bryant, Christopher J.,Scrace, Simon F.,Matassova, Natalia,Baker, Lisa,Dokurno, Pawel,Robinson, David A.,Surgenor, Allan E.,Davis, Ben,Murray, James B.,Richardson, Christine M.,Moore, Jonathan D.
, p. 586 - 590 (2010)
The peptidyl prolyl cis/trans isomerase Pin1 is a promising molecular target for anti-cancer therapeutics. Here we report the structure-guided evolution of an indole 2-carboxylic acid fragment hit into a series of α-benzimidazolyl-substituted amino acids.