1207736-52-4

Upstream product

• 99-91-2 para-chloroacetophenone 
• 135-19-3 β-naphthol 
• 16197-82-3 1,3-bis(4-chlorophenyl)but-2-en-1-one 
• 873-73-4 4-n-chlorophenylacetylene 

Relevant academic research and scientific papers

A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols

Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.

Zinc-Chloride-Promoted Domino Reaction of Phenols with Terminal Alkynes under Solvent-Free Conditions: An Efficient Synthesis of Chromenes

A domino one-pot synthesis of 2H-chromenes and 4H-chromenes starting from phenols and terminal acetylenes in an atom economical reaction under solvent-free conditions is described. This annulation reaction between phenols with alkynes is promoted by the simple Lewis acid ZnCl2. Significantly, to the best of our knowledge, the synthesis of 2H-chromenes is the first of its kind, as it is based on the use of terminal alkyl acetylenes. The described method shows a broad substrate scope and good functional group tolerance.

Efficient Synthesis of Functionalized 4 H -Chromenes via an Fe(OTf) 3 -Catalyzed Cyclization Reaction of Phenols and Ketones

The iron(III) triflate catalyzed cyclization reaction of phenols and ketones is described; the reaction provides a direct approach to 4 H -chromene derivatives. 4 H -Chromene is an important structural fragment of many pharmaceuticals, natural products, and functional materials. The 4 H -chromene synthetic protocol possesses many advantages, such as using readily available and inexpensive starting materials and a non-toxic catalyst, high selectivity, and operational simplicity, which offer attractive industrial prospects from the point of view of green and sustainable chemistry.

Synthesis of functional 4H-chromenes from phenols and acetophenones under solvent- and metal-free conditions

Sulfuric-acid-promoted tandem reaction of phenols with acetophenones under solvent- and metal-free conditions has been developed, which afforded functional 4H-chromenes in good yields with water as the side product. Sulfuric acid appeared to serve the dual role of an efficient promoter and a suitable dehydrating agent.

Gold(III)-catalyzed tandem reaction of ketones with phenols: Efficient and highly selective synthesis of functionalized 4H-chromenes

(Chemical Equation Presented) An efficient and highly selective approach for the synthesis of functionalized 4H-chromenes has been developed via gold(III)-catalyzed condensation/annulation tandem reaction of ketones with phenols.