1207749-49-2Relevant articles and documents
N-Heterocyclic derived M1 positive allosteric modulators
Kuduk, Scott D.,Marco, Christina N. Di,Cofre, Victoria,Pitts, Daniel R.,Ray, William J.,Ma, Lei,Wittmann, Marion,Veng, Lone,Seager, Matthew A.,Koeplinger, Kenneth,Thompson, Charles D.,Hartman, George D.,Bilodeau, Mark T.
scheme or table, p. 1334 - 1337 (2010/07/02)
Replacement of a phenyl ring with N-linked heterocycles in a series of quinolone carboxylic acid M1 positive allosteric modulators was investigated. In particular, a pyrazole derivative exhibited improvements in potency, free fraction, and CNS exposure.