1207750-73-9Relevant articles and documents
Synthesis of glycosaminoglycan oligosaccharides. Part 4: Synthesis of aza-l-iduronic acid-containing analogs of heparan sulfate oligosaccharides as heparanase inhibitors
Csíki, Zsuzsánna,Fügedi, Péter
experimental part, p. 7821 - 7837 (2010/10/21)
The synthesis of three azasugar-containing analogs of the disaccharide units of heparan sulfate, which are potential inhibitors of the enzyme heparanase, is reported. Synthetic routes were developed for the preparation of l-ido-nojirimycin type glycosyl a
The 4-nitrobenzenesulfonyl group as a convenient N-protecting group for iminosugars-synthesis of oligosaccharide inhibitors of heparanase
Csíki, Zsuzsánna,Fügedi, Péter
supporting information; experimental part, p. 391 - 395 (2010/03/04)
The 4-nitrobenzenesulfonyl (nosyl) group can be used advantageously for the protection of the ring nitrogen atom of iminosugars. This group is conveniently introduced, is stable to most of the standard carbohydrate transformations and can be removed under mild conditions. The applicability of the nosyl group is demonstrated by the synthesis of sulfated oligosaccharides which are inhibitors of the enzyme, heparanase. The N-(4-nitrobenzenesulfonyl) group is orthogonal with the azido function.
