1207835-41-3Relevant academic research and scientific papers
Trimethylsilyl chloride as a promoter for the groebke-blackburn reaction: Preparation of imidazo[2,1-b][1,3]benzothiazoles
Tsirulnikov, Sergey,Kysil, Volodymyr,Ivachtchenko, Alexandre,Krasavin, Mikhail
experimental part, p. 111 - 119 (2010/03/24)
2-Amino[1,3]benzothiazoles can be efficiently used as substrates for the Groebke-Blackburn (GB) reaction using equimolar trimethylsilyl chloride (TMSCl) as a promoter. This finding extends the utility of TMSCl in isocyanide-based multicomponent reactions (MCRs) and expands the scope of reactive 2-aminoazole participants for the GBMCR.
