1207843-61-5

Basic information

• Product Name: 3,5-diallyloxy-4-bromo-benzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone
• CAS NO: 1207843-61-5
• Molecular Weight: 499.431
• Mol File: 1207843-61-5.mol

Chemical Properties

• CAS DataBase Reference: 3,5-diallyloxy-4-bromo-benzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-diallyloxy-4-bromo-benzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone(1207843-61-5)
• EPA Substance Registry System: 3,5-diallyloxy-4-bromo-benzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone(1207843-61-5)

Safety Data

• Hazardous Substances Data: 1207843-61-5(Hazardous Substances Data)

Upstream product

• 355121-52-7 3,5-bis-allyloxy-4-bromo-benzaldehyde 
• 40106-45-4 4-hydrazino-5,6-tetramethylenothieno<2,3-d>pyrimidine 

Relevant articles and documents

Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

The synthesis of 2-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone-derivatives (BTPs) and their in vitro evaluation against Trypanosoma cruzi trypomastigotes, Mycobacterium tuberculosis, Leishmania amazonensis axenic amastigotes, and six human cancer cell lines is described. The in vivo activity of the most active and least toxic compounds against T. cruzi and L. amazonensis was also studied. BTPs constitute a new family of drug leads with potential activity against infectious diseases. Due to their drug-like properties, this series of compounds can potentially serve as templates for future drug-optimization and drug-development efforts for use as therapeutic agents in developing countries.

COMPOUNDS, THEIR SYNTHESES, AND THEIR USES

Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).