1207853-15-3

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel-
• Synonyms: 1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel-;rel-benzyl (3r,4r)-3-amino-4-fluoropiperidine-1-carboxylate;(3R,4R)-rel-Benzyl 3-amino-4-fluoropiperidine-1-carboxylate;benzyl trans-3-amino-4-fluoropiperidine-1-carboxylate;Benzyl (3R,4R)-3-amino-4-fluoro-piperidine-1-carboxylate;TRANS-1-CBZ-4-FLUORO-3-PIPERIDINAMINE
• CAS NO: 1207853-15-3
• Molecular Formula: C13H17FN2O2
• Molecular Weight: 252.2846832
• Mol File: 1207853-15-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 375.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• PKA: 9.11±0.40(Predicted)
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel-(1207853-15-3)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel-(1207853-15-3)

Safety Data

• Hazardous Substances Data: 1207853-15-3(Hazardous Substances Data)

Usage

General Description

The chemical "1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel-" is a specific organic compound with the molecular formula C15H20FN3O2. It has a piperidine ring and a carboxylic acid functional group, as well as an amino and fluoro substituent. The phenylmethyl ester group is also present, with the (3R,4R)-rel- configuration specifying the stereochemistry of the molecule. 1-Piperidinecarboxylic acid, 3-aMino-4-fluoro-, phenylMethyl ester, (3R,4R)-rel- may have potential applications in medicinal chemistry and drug development due to its unique structure and properties.

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 1052713-39-9 (3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate 
• 1052713-48-0 tert-butyl ((3S,4S)-4-fluoropiperidin-3-yl)carbamate 
• 859854-67-4 3-tert-butoxycarbonylamino-4-hydroxypiperidine-1-carboxylic acid benzyl ester 
• 66207-08-7 3,4-epoxy-piperidine-1-carboxylic acid benzyl ester 
• 1214242-81-5 (3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-fluoropiperidine-1-carboxylate 

Downstream Products

• 1052713-46-8 (+/-)-tert-butyl ((cis)-4-fluoropiperidin-3-yl)carbamate 

Relevant articles and documents

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

AMINOPYRIDAZINONE COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present disclosure provides a compound of formula (I) and the use thereof for the therapeutic treatment of human cancers including B-cell lymphoma and autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.

6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.