1207861-02-6

Basic information

• Product Name: methyl 4-{1-[({2,5-dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate
• Synonyms: methyl 4-{1-[({2,5-dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate
• CAS NO: 1207861-02-6
• Molecular Weight: 487.543
• Mol File: 1207861-02-6.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-{1-[({2,5-dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-{1-[({2,5-dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate(1207861-02-6)
• EPA Substance Registry System: methyl 4-{1-[({2,5-dimethyl-4-[3-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate(1207861-02-6)

Safety Data

• Hazardous Substances Data: 1207861-02-6(Hazardous Substances Data)

Upstream product

• 1006037-03-1 4-(1-aminocyclopropyl)-benzoic acid methyl ester 
• 1207860-97-6 2,5-dimethyl-4-[3-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid 

Relevant articles and documents

The discovery of 4-{l-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]- 3thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin e2 subtype 4 receptor antagonist

The discovery of highly potent and selective second generation EP4 antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.