1207861-07-1

Basic information

• Product Name: methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate
• Synonyms: methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate
• CAS NO: 1207861-07-1
• Molecular Weight: 431.915
• Mol File: 1207861-07-1.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate(1207861-07-1)
• EPA Substance Registry System: methyl 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate(1207861-07-1)

Safety Data

• Hazardous Substances Data: 1207861-07-1(Hazardous Substances Data)

Upstream product

• 1207861-06-0 methyl 4-[1-({[2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate 

Downstream Products

• 1207861-03-7 4-[1-({[5-chloro-2-(3-fluorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acid 

Relevant articles and documents

The discovery of 4-{l-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]- 3thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin e2 subtype 4 receptor antagonist

The discovery of highly potent and selective second generation EP4 antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.