1207862-70-1

Upstream product

• 1006049-48-4 1-ethyl 4-methyl 2-(2,2,2-trifluoroacetyl)succinate 
• 1006049-56-4 7-amino-4-trifluoromethyl-3-(carbomethoxymethyl)quinolin-2(1H)-one 
• 1006049-47-3 2-(7-amino-2-oxo-4-(trifluoromethyl)-1,2-dihydroquinolin-3-yl)acetic acid 
• 149834-58-2 1-triphenylmethyl-1,6-diaminohexane 

Relevant academic research and scientific papers

Luminescent probes for ultrasensitive detection of nucleic acids

Novel amino-reactive derivatives of lanthanide-based luminescent labels of enhanced brightness and metal retention were synthesized and used for the detection of cDNA oligonucleotides by molecular beacons. Time-resolved acquisition of the luminescent signal that occurs upon hybridization of the probe to the target enabled the avoidance of short-lived background fluorescence, markedly enhancing the sensitivity of detection, which was less than 1 pM. This value is about 50 to 100 times more sensitive than the level achieved with conventional fluorescencebased molecular beacons, and is 10 to 60 times more sensitive than previously reported for other lanthanidebased hybridization probes. These novel luminescent labels should significantly enhance the sensitivity of all type of nucleic acid hybridization probes, and could dramatically improve the detection limit of other biopolymers and small compounds that are used in a variety of biological applications.

FLUOROPHORE CHELATED LANTHANIDE LUMINESCENT PROBES WITH IMPROVED QUANTUM EFFICIENCY

The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.