1207868-58-3Relevant academic research and scientific papers
Structure and activity relationship of 2-(substituted benzoyl)- hydroxyindoles as novel CaMKII inhibitors
Komiya, Masafumi,Asano, Shigehiro,Koike, Nobuyuki,Koga, Erina,Igarashi, Junetsu,Nakatani, Shogo,Isobe, Yoshiaki
, p. 1456 - 1458 (2011/04/16)
A series of novel 2-substituted-5-hydroxyindoles were synthesized and evaluated for their inhibitory activity against CaMKII. Structure and activity relationship results indicated that potent inhibitory activity could be achieved by modification at the para-position of the phenyl ring of the high throughput screening hit compound 2. Among the prepared compounds, we identified 14 as a novel CaMKII inhibitor with an activity stronger than that of KN-93, a known CaMKII inhibitor.
