1207868-79-8

Basic information

• Product Name: C₂₁H₁₄BrNO₃
• CAS NO: 1207868-79-8
• Molecular Weight: 408.251
• Mol File: 1207868-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₄BrNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₄BrNO₃(1207868-79-8)
• EPA Substance Registry System: C₂₁H₁₄BrNO₃(1207868-79-8)

Safety Data

• Hazardous Substances Data: 1207868-79-8(Hazardous Substances Data)

Upstream product

• 106792-38-5 5-(tert-butyl-dimethyl-silanyloxy)-1H-indole 
• 1207869-50-8 C₂₇H₃₁NO₃Si 
• 67-36-7 4-phenoxy benzaldehyde 

Relevant articles and documents

Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5- hydroxyindole as a novel CaMKII inhibitor

Based on 2-(4-phenoxybenzoyl)-5-hydroxyindole (2), a novel structural class of CaMKII inhibitors were synthesized and further optimized. The strong acidity of the hydroxyl group and the lipophilic group at the 4 and 6-positions were found to be necessary for strong CaMKII inhibition. Compound 25 was identified as a promising compound with 50-fold more potent inhibitory activity for CaMKII than 2. Compound 25 also showed high selectivity for CaMKII over off-target kinases.