120788-80-9

Upstream product

• 85994-60-1 (4R,5R)-5-Ethyl-2,2,4-trimethyl-1,3-dioxolan-4-carbonsaeure-methylester 
• 85994-61-2 (4S,5R)-5-Ethyl-2,2,4-trimethyl-1,3-dioxolan-4-carbonsaeure-methylester 
• 120850-98-8 methyl (2R,3R)-2,3-dihydroxy-2-methylpentanoate 
• 931-94-2 1,1-dimethoxycyclopentane 
• 120788-79-6 methyl (2R,3R)-3-ethyl-2-methyl-1,4-dioxaspiro<4.4>nonane-2-carboxylate 
• 120788-79-6 methyl (2R,3R)-3-ethyl-2-methyl-1,4-dioxaspiro<4.4>nonane-2-carboxylate 

Downstream Products

• 534-32-7 methynolide 

Relevant academic research and scientific papers

Total Synthesis of Methynolide

In this paper the synthesis of methynolide (1), the aglycone of methymycin, a 12-membered macrolide antibiotic is described.We have used the chiral C-1 to C-8 segment 10 which has been combined with the C-9 to C-13 segment 9 to form the carbon skeleton of methynolide.Cyclization of the seco-acid 14 has been accomplished by intramolecular esterification.

Stereoselective Synthesis of Alcohols, XXXI. - Stereoselective C-C Bond Formation Using Chiral Z-Pentenylboronates

Using 1,2-dicyclohexyl-1,2-ethanediol as chiral auxiliary, the enantiomerically pure Z-pentenylboronate 9c was obtained.Its addition to benzaldehyde proceeded with complete transfer of chirality to give the syn-E-homoallyl alcohol 11.The ability of the re