1207957-99-0Relevant academic research and scientific papers
Palladium-catalyzed intermolecular addition of formamides to alkynes
Fujihara, Tetsuaki,Katafuchi, Yuko,Iwai, Tomohiro,Terao, Jun,Tsuji, Yasushi
supporting information; experimental part, p. 2094 - 2098 (2010/04/24)
A novel palladium system for an intermolecular addition of formamides to alkynes has been developed. The reaction of formamides with internal alkynes in the presence of a palladium catalyst with acid chloride as an additive afforded (E)-α,β-unsaturated amides regio- and stereoselectively. The same catalyst system realized the first example of the addition of formamides to terminal alkynes giving the corresponding α,β-unsaturated amides bearing a terminal methylene moiety as major products. The present reaction was widely applicable to substrates with various functionalities. This method also could be applied to the reaction of N,N-disubstituted formamides with norbornene. A hydridopalladium species would be formed as a key intermediate with in situ generated HCl under the reaction conditions.
