1207961-06-5Relevant articles and documents
Silicon switch approach in TRPV1 antagonist MK-056 and its analogues
Chang, Minsun,Park, Seol-Rin,Kim, Juhyun,Jang, Mijung,Park, Jeong Hyun,Park, Ji Eun,Park, Hyeung-Geun,Suh, Young-Ger,Jeong, Yeon Su,Park, Young-Ho,Kim, Hee-Doo
, p. 111 - 116 (2010)
In searching for opportunities to exploit the benefits of silicon in TRPV1 research, we tried to investigate the pharmacological effects of sila-substitution (C/Si exchange) of tert-butyl group in the MK-056 series. Compound 13a, with a 4-positioned trime