1207973-80-5

Upstream product

• 1026022-29-6 O-(16-O-triethylsilyl-quillaic acid) 4-O-triethylsilyl-[(2,3,4-tri-O-triethylsilyl-β-D-xylopyranosyl)-(1-3)]-[(2,3,4,6-tetra-O-triethylsilyl-β-D-galactopyranosyl)-(1-2)]-β-D-glucuronoside benzyl ester 
• 1207973-73-6 C₆₉H₇₅Cl₃N₄O₁₇ 

Downstream Products

• 1207973-81-6 C₁₇₅H₂₇₉NO₃₆Si₉ 

Relevant academic research and scientific papers

TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF

The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.