1208004-83-4Relevant academic research and scientific papers
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability
Xue, Fengtian,Fang, Jianguo,Lewis, William W.,Martasek, Pavel,Roman, Linda J.,Silverman, Richard B.
supporting information; experimental part, p. 554 - 557 (2010/04/26)
Recently, a series of potent and selective neuronal nitric oxide synthase inhibitors containing two basic nitrogen atoms was reported (Ji, H.; Stanton, B. Z.; Igarashi, J.; Li, H.; Martasek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. J. Am. Chem. Soc. 2008, 130, 3900-3914). In an effort to improve their bioavailability, three compounds (2a-c) were designed with electron-withdrawing groups near one of the basic nitrogen atoms to lower its pKa. Inhibition studies with these compounds showed that two of them not only retained most of the potency and selectivity of the best analogue of the earlier series, but also showed improved membrane permeability based on data from a cell-based assay.
Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors with Improved Membrane Permeability
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, (2010/08/07)
Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS WITH IMPROVED MEMBRANE PERMEABILITY
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Page/Page column 36, (2010/08/08)
Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
