1208065-18-2Relevant academic research and scientific papers
A general approach to indole-7-yl derivatives of isoxazole, oxadiazole, thiadiazole and pyrazole
Polozov, Alexandre M.,Hategan, Georgeta,Cao, Hua,Kiselyov, Alex S.,Zeller, Wayne,Singh, Jasbir
scheme or table, p. 575 - 578 (2010/04/02)
Isosteric replacement of the α,β-unsaturated amide at the C-7 position of indoles with a diverse set of five-membered amino-heterocycles including isoxazole, oxadiazole, thiadiazole and pyrazole followed by subsequent derivatization of the heterocyclic amino group to yield amides, sulfonamides and phosphoramides is described. Distinctive features of these procedures include the versatility and robust nature of the synthetic steps along with the high yields of the targeted molecules.
