1208066-20-9

Basic information

• Product Name: 7-(allyloxy)-3-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one
• Synonyms: 7-(allyloxy)-3-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one
• CAS NO: 1208066-20-9
• Molecular Weight: 322.317
• Mol File: 1208066-20-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(allyloxy)-3-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(allyloxy)-3-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one(1208066-20-9)
• EPA Substance Registry System: 7-(allyloxy)-3-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one(1208066-20-9)

Safety Data

• Hazardous Substances Data: 1208066-20-9(Hazardous Substances Data)

Upstream product

• 90-29-9 7-hydroxy-3',4'-methylenedioxyisoflavone 
• 106-95-6 allyl bromide 

Relevant articles and documents

The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone

The natural products novobiocin and derrubone have both demonstrated Hsp90 inhibition and structure-activity relationships have been established for each scaffold. Given these compounds share several key structural features, we hypothesized that incorporation of elements from each could provide insight to structural features important for Hsp90 inhibition. Thus, chimeric analogues of novobiocin and derrubone were constructed and evaluated. These studies confirmed that the functionality present at the 3-position of the isoflavone plays a critical role in determining Hsp90 inhibition and suggests that the bicyclic ring system present in both novobiocin and derrubone do not share similar modes of binding.