1208081-18-8

Basic information

• Product Name: 1-(3-broMophenyl)-1H-pyrazole-4-carbonitrile
• Synonyms: 1-(3-broMophenyl)-1H-pyrazole-4-carbonitrile
• CAS NO: 1208081-18-8
• Molecular Formula: C₁₀H₆BrN₃
• Molecular Weight: 248.07874
• Mol File: 1208081-18-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.5±22.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: -4.53±0.12(Predicted)
• CAS DataBase Reference: 1-(3-broMophenyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-broMophenyl)-1H-pyrazole-4-carbonitrile(1208081-18-8)
• EPA Substance Registry System: 1-(3-broMophenyl)-1H-pyrazole-4-carbonitrile(1208081-18-8)

Safety Data

• Hazardous Substances Data: 1208081-18-8(Hazardous Substances Data)

Usage

General Description

1-(3-bromophenyl)-1H-pyrazole-4-carbonitrile is a chemical compound that belongs to the class of pyrazole derivatives. It is characterized by the presence of a pyrazole ring with a cyano group at the 4th position and a bromine-substituted phenyl group at the 1st position. 1-(3-broMophenyl)-1H-pyrazole-4-carbonitrile has potential applications in pharmaceutical and agrochemical industries, where it may be used as a building block for the synthesis of various biologically active molecules, such as antiviral and anticancer agents. Its chemical structure and properties make it a valuable tool for medicinal chemistry research and drug discovery efforts. Additionally, its unique structure may also confer useful biological activities that can be explored for various therapeutic purposes.

Upstream product

• 71856-56-9 5-amino-1-(3-bromophenyl)-1H-pyrazole-4-carbonitrile 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 

Downstream Products

• 1350554-95-8 1-(3-bromophenyl)-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole 
• 1431459-32-3 5-[1-(3-bromophenyl)-1H-pyrazole-4-yl]-1H-tetrazole 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

An efficient synthesis of new 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitriles via [3 + 2] cycloaddition reaction

A series of new 5-(1-aryl-1H-pyrazole-4-yl)-1H-tetrazoles 4a-l were synthesized via [3 + 2] cycloaddition reaction from 1-aryl-1H-pyrazole-4- carbonitriles 3a-l, sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yields: 64-85%. The structures of these newly synthesized compounds were determined from the IR, 1H- and 13C-NMR spectroscopic data and elemental analyses.