120810-81-3

Upstream product

• 120810-80-2 2-((S)-2-[1,3]Dithiolan-2-yl-propyl)-2-methyl-[1,3]dithiolane 
• 120810-93-7 (2S,4S,5R)-2-((S)-3-Hydroxy-1-methyl-butyl)-4-methyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 120851-83-4 (2S,4S,5R)-4-Methyl-2-((S)-1-methyl-3-oxo-butyl)-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 120810-91-5 (2S,4S,5R)-2-((E)-3-Hydroxy-but-1-enyl)-4-methyl-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 120810-77-7 (2S,4S,5R)-4-Methyl-2-((S)-1-methyl-3-oxo-propyl)-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 120828-08-2 (2S,4S,5R)-4-Methyl-2-((E)-3-oxo-but-1-enyl)-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 220077-33-8 (3R,4R,R_S)-5,5-ethylenedioxy-4-methyl-3-[(2,4,6-triisopropylphenyl)sulfinyl]-2-pentanone 
• 207983-99-1 (S,E)-3-[(2,4,6-triisopropylphenyl)sulfinyl]-3-pentene-2-one 
• 220077-39-4 5,5-ethylenedioxy-4-methyl-2-pentanone 

Relevant academic research and scientific papers

Total synthesis of zincophorin and its methyl ester

A total synthesis of the naturally occurring ionophore zincophorin has been realized. The route features an intramolecular oxymercuration of a cyclopropanemethanol and a Carroll-Claisen rearrangement for the respective elaboration of the C1-C12 and C13-C25 subunits, which have been assembled by using a highly diastereoselective titanium-mediated aldol condensation.

Total Synthesis of Zincophorin Methyl Ester

(Equation presented) A convergent total synthesis of the methyl ester of zincophorin, an ionophore antibiotic, has been realized relying on a diastereoselective titanium-mediated aldol coupling between the C1-C12 and C13-C25 subunits. The latter fragment

Photo-induced intermolecular radical β-addition to chiral α- (arylsulfinyl) enones

The reactions of α-(arylsulfinyl) enones with alkyl radicals having a hydroxy or acetal group were examined under photo-irradiation in the presence of benzophenone. High diastereoselectivity was observed in the photo-induced radical reaction of 2-(arylsulfinyl)-2-cyclopentenones having a bulky aryl group, such as the 2,4,6-triisopropylphenyl or 2,4, 6-trimethylphenyl group. The photo-induced reaction of 3-[(2,4,6-triisopropylphenyl)sulfinyl]-3- pentene-2-one in 1,3-dioxolane also gave a single diastereomer of the 1,3- dioxolan-2-yl adduct.

ALLYLIC STEREOCENTER DIRECTED ASYMMETRIC CONJUGATE ADDITION OF CUPRATES IN THE PRESENCE OF TRIMETHYLCHLOROSILANE. ENANTIOSELECTIVE SYNTHESIS OF 2-ALKYL-4-BENZYLOXYBUTANAL AND 2-ALKYL-4-OXOPENTANAL.

Cuprate reagents in the presence of trimethylchlorosilane add with excellent Π-face selectivity and yield to α,β-unsaturated ketone and aldehyde bearing in γ-position a masked aldehyde represented by the C-2 of a norephedrine-derived oxazolidine.The title