1208112-47-3

Basic information

• Product Name: 3,5-bis-(2-hydroxyphenyl)-1N-(4-methylbenzenesulphonyl)-4,5-dihydro-1H-pyrazole
• CAS NO: 1208112-47-3
• Molecular Weight: 408.478
• Mol File: 1208112-47-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,5-bis-(2-hydroxyphenyl)-1N-(4-methylbenzenesulphonyl)-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis-(2-hydroxyphenyl)-1N-(4-methylbenzenesulphonyl)-4,5-dihydro-1H-pyrazole(1208112-47-3)
• EPA Substance Registry System: 3,5-bis-(2-hydroxyphenyl)-1N-(4-methylbenzenesulphonyl)-4,5-dihydro-1H-pyrazole(1208112-47-3)

Safety Data

• Hazardous Substances Data: 1208112-47-3(Hazardous Substances Data)

Upstream product

• 55370-67-7 3,5-bis-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazole 
• 98-59-9 p-toluenesulfonyl chloride 
• 34000-30-1 2',2-dihydroxychalcone 

Relevant articles and documents

Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis

Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) produce siderophores with scaffolds of nonribosomal peptide-polyketide origin. Compounds with structural similarities to these siderophores were synthesized and evaluated as antimicrobials against Mtb and Yp under iron-limiting conditions mimicking the iron scarcity these pathogens encounter in the host and under standard iron-rich conditions. Several new antimicrobials were identified, including some with increased potency in the iron-limiting condition. Our study illustrates the possibility of screening compound libraries in both iron-rich and iron-limiting conditions to identify antimicrobials that may selectively target iron scarcity-adapted bacteria and highlights the usefulness of building combinatorial libraries of compounds having scaffolds with structural similarities to siderophores to feed into antimicrobial screening programs.