1208114-40-2Relevant academic research and scientific papers
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors
Dietrich, Justin,Gokhale, Vijay,Wang, Xiadong,Hurley, Laurence H.,Flynn, Gary A.
experimental part, p. 292 - 304 (2010/04/02)
B-Raf protein kinase, which is a key signaling molecule in the RAS-RAF-MEK-ERK signaling pathway, plays an important role in many cancers. The B-Raf V600E mutation represents the most frequent oncogenic kinase mutation known and is responsible for increas
