1208117-61-6

Basic information

• Product Name: (2-(3-cyclohexylprop-1-en-2-yl)phenyl)carbamoyl cyanide
• Synonyms: (2-(3-cyclohexylprop-1-en-2-yl)phenyl)carbamoyl cyanide
• CAS NO: 1208117-61-6
• Molecular Weight: 268.359
• Mol File: 1208117-61-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-(3-cyclohexylprop-1-en-2-yl)phenyl)carbamoyl cyanide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(3-cyclohexylprop-1-en-2-yl)phenyl)carbamoyl cyanide(1208117-61-6)
• EPA Substance Registry System: (2-(3-cyclohexylprop-1-en-2-yl)phenyl)carbamoyl cyanide(1208117-61-6)

Safety Data

• Hazardous Substances Data: 1208117-61-6(Hazardous Substances Data)

Upstream product

• 1208117-82-1 C₁₅H₂₁N 
• 3189-43-3 tetracyanoethylene oxide 

Downstream Products

• 1208117-62-7 (S)-2-(3-(cyclohexylmethyl)-2-oxoindolin-3-yl)acetonitrile 

Relevant articles and documents

Catalytic C-CN activation and asymmetric cyanoamidation of alkenes: Total syntheses of (+)-horsfiline, (-)-coerulescine, and (-)-esermethole

The detailed study of Pd-catalyzed asymmetric cyanoamidation is reported. Excellent enantioselectivities are attributed to a chiral phosphosphoramidite ligand synthesized in one step from the commercially available materials. Cyanoamidation substrates are easy to prepare from the corresponding anilines. The 3,3-disubstituted oxindole products bear all-carbon quaternary stereocenters and contain a nitrile and an amide, which are valuable functional handles for the synthesis of many indole-containing natural products. Cyanoamidation tolerates free N-H groups, as demonstrated by the successful use of cyanoamidation in the syntheses of (+)-horsfiline and (-)-coerulescine.