1208129-52-5Relevant academic research and scientific papers
General methodology for the preparation of 2,5-disubstituted-1,3-oxazoles
Williams, David R.,Fu, Liangfeng
, p. 808 - 811 (2010)
Chemical equation presented Deprotonation of 2-(phenylsulfonyl)-1,3-oxazole (1) readily provides a useful C-5 carbanion that is reactive with a variety of electrophiles. Aldehydes and ketones are useful substrates, and the formation of 5-iodo- and 5-tri-n-butylstannyl oxazoles affords access to cross-coupling reactions. Subsequent nucleophilic displacement of the 2-phenylsulfonyl group provides a general route for the synthesis of 2,5-disubstituted-1,3-oxazoles.
