1208222-55-2Relevant articles and documents
Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1
Bernardo, Paul H.,Sivaraman, Thirunavukkarasu,Wan, Kah-Fei,Xu, Jin,Krishnamoorthy, Janarthanan,Sons, Chun Meng,Tian, Liming,Chin, Jasmine S. F.,Lim, Diane S. W.,Mok, Henry Y. K.,Yu, Victor C.,Tong, Joo Chuan,Chai, Christina L. L.
, p. 2314 - 2318 (2010)
The screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with mutant proteins and in silico docking studies provide a possible rationale for the observed specificity.
